I was a big fan of Zope early on (late 90's) and always wanted to do some fun web-based projects. One of the more successful ones was LaTeXWiki, which was one of the first wiki plugins where you could write LaTeX. Unfortunately, I was always sufficiently confused about some aspect of Zope that most of my projects only worked out with the help of friends like Sean, Joe, Jeff, Bob, and Stephen.
The old theoryandpractice site ran on Zope, but it hasn't been touched in years. I spent so much time getting a 3-collumn CSS layout back in the early CSS days that it basically killed my interest. Now I'm rebooting theoryandpractice.org (love that name) with wordpress and I'm hoping to tinker with some of the new technologies like D3 and Flask. Wish me luck!